Publications


LANGEBIO Cinvestav, Mexico

Lab Publications

Nature

64. Sohail M, Palma-Martínez MJ, Chong AY, Quinto-Cortés CD, Barberena-Jonas C, (...Moreno-Estrada, A.). (2023). Mexican Biobank advances population and medical genomics of diverse ancestries. Nature. [link]

AJHG

64. Medina-Muñoz SG, Ortega-Del Vecchyo D, Cruz-Hervert LP, Ferreyra-Reyes L, García-García L, (...Moreno-Estrada, A.), Ragsdale AP. (2023). Demographic modeling of admixed Latin American populations from whole genomes. Mol Ecol. [link]

NatCommun

64. Nigenda-Morales SF, Lin M, Nuñez-Valencia PG, Kyriazis CC, Beichman AC, Robinson JA, (...Moreno-Estrada, A.), Wayne RK. (2023). The genomic footprint of whaling and isolation in fin whale populations. Nat Commun. [link]

Diabetology

63. Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, (...Moreno-Estrada, A.). (2023). Mexican Biobank; Aguilar-Salinas CA, Tusié T, Dupuis J, Ng MCY, Manning A, Highland HM, Cnop M, Hanson R, Below J, Florez JC, Leong A, Mercader JM. The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes. Diabetology. [link]

MolEcol

62.Beichman AC, Robinson J, Lin M, (...Moreno-Estrada, A.), Nigenda-Morales S, Harris K. (2023). Evolution of the Mutation Spectrum Across a Mammalian Phylogeny. Mol Ecol. [link]

MolEcol

61. Beichman AC, Kalhori P, Kyriazis CC, DeVries AA, Nigenda-Morales S, Heckel G, Schramm Y., (...Moreno-Estrada, A.), Kennett DJ, Hylkema M, Bodkin J, Koepfli KP, Lohmueller KE, Wayne RK. (2023). Genomic analyses reveal range-wide devastation of sea otter populations. Mol Ecol. [link]

Science

60. Villa-Islas, V., Izarraras-Gomez, A., Larena, M., Campos, E. M. P., Sandoval-Velasco, M., Rodríguez-Rodríguez, J. E., (...Moreno-Estrada, A.) & Ávila-Arcos, M. C. (2023). Demographic history and genetic structure in pre-Hispanic Central Mexico. Science. [link]

BioRxiv

58. Sohail M., Chong A., Quinto-Cortés C., Medina S., Barberena C., Ferreyra L., (...), Novembre J., Garcia-Garcia L., Moreno-Estrada A. (2022). Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals. BioRxiv. [link]

MBE

57. Caro-Consuegra, R., Nieves-Colón, M. A., Rawls, E., Rubin-de-Celis, V., Lizárraga,B., Vidaurre, T., (...Moreno-Estrada, A.) & Bosch, E. (2022). Uncovering signals of positive selection in Peruvian populations from three ecological regions. Molecular Biology and Evolution. [link]

Science

56. Liu, Y. C., Hunter-Anderson, R.,Cheronet, O., Eakin, J., Camacho, F.,Pietrusewsky, M., (...Moreno-Estrada, A.) & Reich, D.(2022). Ancient DNA reveals five streams of migration into Micronesia and matrilocality in early Pacific seafarers. Science. [link]

AJHG

55. Nieves-Colón, M. A., Rivera, K. M. B., Sandoval, K., Dávalos, V. V., Lencinas, L. E. E., Mendoza-Revilla, J., ... & Moreno-Estrada, A. (2022). Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes. The American Journal of Human Genetics. [link]

Journal of Experimental Medicine

54. Bastard, P., Hsiao, K. C., Zhang, Q., Choin, J., Best, E., Chen, J., (...Moreno-Estrada A.) & Casanova, J. L. (2022). A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes. Journal of Experimental Medicine. [link]

MBE

53. Mendoza-Revilla, J., Chacón-Duque, J. C., Fuentes-Guajardo, M., Ormond, L., Wang, K., Hurtado, M., (...Moreno-Estrada A.), & Hellenthal, G. (2022). Disentangling signatures of selection before and after European colonization in Latin Americans. Molecular Biology and Evolution. [link]

Philosophical Transactions of the Royal Society B

52. Rodriguez-Rodriguez, J. E., Ioannidis, A. G., Landa-Chavarria, E., Blanco-Portillo, J., Quinto-Cortes, C. D., Penaloza-Espinosa, R. I., ... & Moreno-Estrada, A. (2022). The genetic legacy of the Manila Galleon trade in Mexico. Philosophical Transactions of the Royal Society B. [link]

MolEcology

51. Beichman, A. C., Kalhori, P., Kyriazis, C. C., DeVries, A. A., Nigenda-Morales, S., Heckel, G., ... & Wayne, R. K.(2021). Genomic analyses reveal range‐wide devastation of sea otter populations. Molecular Ecology [link]

FrontiersGenetics

50. Jiménez-Kaufmann, A., Chong, A. Y., Cortés, A., Fernandez-Valverde, S. L., Ferreyra-Reyes, L., Cruz-Hervert, P., ... & Moreno-Estrada, A.(2021). Imputation performance in Latin American populations: improving rare variants representation with the inclusion of Native American genomes. Frontiers in Genetics [link]

MBE

49. Ojeda-Granados C, Abondio P, Setti A, Sarno S, Gnecchi-Ruscone GA, González-Orozco E, De Fanti S, Jiménez-Kaufmann A, Rangel-Villalobos H, Moreno-Estrada A, Sazzini M.(2021). Dietary, Cultural and Pathogens-Related Selective Pressures Shaped Differential Adaptive Evolution Among Native Mexican Populations. Mol Biol Evol [link]

medRxiv

48. Rivera, K. M. B., Nieves-Colon, M. A., Mendoza, K. S., Davalos, V. V., Lencinas, L. E. E., Chen, J. W., ... & Moreno-Estrada, A. (2021). Clotting factor genes are associated with preeclampsia in high altitude pregnant women in the Peruvian Andes. medRxiv [link]

Nature

47. Ioannidis, A. G.,Blanco-Portillo, J.,Sandoval, K., Hagelberg, E., Barberena-Jonas, C., Hill, A. V., ... & Moreno-Estrada, A. (2021). Paths and timings of the peopling of Polynesia inferred from genomic networks. Nature [link]

Nature

46. COVID-19 Host Genetics Initiative (2021). Mapping the human genetic architecture of COVID-19. Nature [link]

Nature

45. Ioannidis, A. G., Blanco-Portillo, J., Sandoval, K., Hagelberg, E., Miquel-Poblete, J. F., Moreno-Mayar, J. V., ... & Moreno-Estrada A. (2020). Native American gene flow into Polynesia predating Easter Island settlement. Nature [link]

Peer J

44. Ávila-Arcos, M. C., McManus, K. F., Sandoval, K., Rodríguez-Rodríguez, J. E., Martin, A. R., Luisi, P., Villa-Islas V, Peñaloza-Espinosa RI, Eng C, Huntsman S., Burchard EG., Gignoux CR., Bustamante CD., Moreno-Estrada A. (2019). Population history and gene divergence in Native Mexicans inferred from 76 human exomes. MBE [link]

Peer J

43. Ongaro L., Scliar M.O., Flores R., Raveane A., Marnetto D., Sarno S., (… Moreno-Estrada A.,…) & Montinaro F. (2019). The genomic impact of European colonization of the Americas. Current Biology 29(23): 3974–3986. [link]

Peer J

42. Wojcik, G. L., Graff, M., Nishimura, K. K., Tao, R., Haessler, J., Gignoux, C. R., (…Moreno-Estrada A.,…) & Carlson C.S. (2019). Genetic analyses of diverse populations improves discovery for complex traits. Nature 570(7762): 514-518. [link]

Peer J

41. Gignoux, C. R., Torgerson, D. G., Pino-Yanes, M., Uricchio, L. H., Galanter, J., Roth, L. A., (…Moreno-Estrada A.,…) & Mathias, R. A. (2019). An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos. Journal of Allergy and Clinical Immunology 143(3):957-969. [link]

Peer J

40. Huerta-Chagoya, A., Moreno-Macías, H., Fernández-López, J. C., Ordóñez-Sánchez, M. L., Rodríguez-Guillén, R., Contreras, A Hidalgo-Miranda A., Alfaro-Ruíz L.A., Salazar-Fernandez E.P., Moreno-Estrada A. and Aguilar-Salinas, C.A. (2019). A panel of 32 AIMs suitable for population stratification correction and global ancestry estimation in Mexican mestizos. BMC Genetics 20(1): 1-11. [link]

39. Mak, A. C., White, M. J., Eckalbar, W. L., Szpiech, Z. A., Oh, S. S., Pino-Yanes, (…Moreno-Estrada A.,…) & Esteban G Burchard, on behalf of the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. (2018) Whole Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma. Am. J. Respir. Crit. Care Med 6, e4512. [link]

Peer J

38. De la Fuente, C., Ávila-Arcos, M.C., Galimany, J., Carpenter, M.L., Homburger, J.R., Blanco, A., Contreras, P., Dávalos, D.C., Reyes, O., San Roman, M. & Moreno-Estrada, A. (2018). Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia. PNAS 201715688. [link]

Peer J

37. Belbin, G. M., Nieves-Colón, M. A., Kenny, E. E., Moreno-Estrada, A., & Gignoux, C. R (2018). Genetic diversity in populations across Latin America: implications for population and medical genetic studies. Current opinion in genetics & development (53), 98-104 [link]

Peer J

36. Nigenda-Morales, S. F., Harrigan, R. J., & Wayne, R. K. (2018). Playing by the rules? Phenotypic adaptation to temperate environments in an American marsupial. PeerJ 6, e4512. [link]

Molecular Ecology

35. Nigenda‐Morales, S. F., Hu, Y., Beasley, J., Ruiz‐Piña, H. A., Valenzuela‐Galván, D., & Wayne, R. K. (2018). Transcriptomic analysis of skin pigmentation variation in the Virginia opossum (Didelphis virginiana). Molecular Ecology . [link]

Scienticic Reports

34. Quinto-Cortés, C. D., Woerner, A. E., Watkins, J. C., & Hammer, M. F. (2018). Modeling SNP array ascertainment with Approximate Bayesian Computation for demographic inference. Scientific Reports 8(1), 10209. [link]

AJPA

33. Nieves‐Colón, M. A., Ozga, A. T., Pestle, W. J., Cucina, A., Tiesler, V., Stanton, T. W., & Stone, A. C. (2018). Comparison of two ancient DNA extraction protocols for skeletal remains from tropical environments. American Journal of Physical Anthropology . [link]

BMC

32. Cruz-Dávalos, D. I., Nieves-Colón, M. A., Sockell, A., Poznik, G. D., Schroeder, H., Stone, A. C., ... & Ávila-Arcos, M. C. (2018). In-solution Y-chromosome capture-enrichment on ancient DNA libraries. BMC Genomics,19(1), 608. [link]

Current Opinion

31. Belbin, G. M., Nieves-Colón, M. A., Kenny, E. E., Moreno-Estrada, A., & Gignoux, C. R. (2018). Genetic diversity in populations across Latin America: implications for population and medical genetic studies. Current Opinion in Genetics & Development,53, 98-104. [link]

Nature

30. Mallick, S., Li, H., Lipson, M., Mathieson, I., Gymrek, M., Racimo, F., ... & Skoglund, P. (2016). The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. [link]

AR

29. Alarcón‐Riquelme, M. E., Ziegler, J. T., Molineros, J., Howard, T. D., Moreno‐Estrada, A., Sánchez‐Rodríguez, E., ... & Kelly, J. A. (2016). Genome‐Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. Arthritis & Rheumatology, 68(4), 932-943. [link]

GD

28. Arteaga, M. C., Moreno-Letelier, A., Mastretta-Yanes, A., Vázquez-Lobo, A., Breña-Ochoa, A., Moreno-Estrada, A., ... & Piñero, D. (2016). Genomic variation in recently collected maize landraces from Mexico. Genomics Data, 7, 38-45. [link]

PLOS

27. Homburger, J., Moreno-Estrada, A., Gignoux, C., Nelson, D., Sanchez, E., Ortiz-Tello, P., . . . Bustamante, C. (2015). Genomic Insights into the Ancestry and Demographic History of South America. PLOS Genetics, 1-26. doi:10.1371/journal.pgen.1005602 [link]

Science

26. Raghavan, M., Steinrücken, M., Harris, K., Schiffels, S., Rasmussen, S., DeGiorgio, M., ... & Eriksson, A. (2015). Genomic evidence for the Pleistocene and recent population history of Native Americans. Science, 349(6250), aab3884. [link]

Imm

25. Pino-Yanes, M., Gignoux, C. R., Galanter, J. M., Levin, A. M., Campbell, C. D., Eng, C., ... & O'Roak, B. J. (2015). Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. Journal of Allergy and Clinical Immunology, 135(6), 1502-1510. [link]

Imm

24. Pino-Yanes, M., Thakur, N., Gignoux, C. R., Galanter, J. M., Roth, L. A., Eng, C., ... & Nguyen, E. A. (2015). Genetic ancestry influences asthma susceptibility and lung function among Latinos. Journal of Allergy and Clinical Immunology, 135(1), 228-235. [link]

Other Selected Publications

Science

23. Moreno-Estrada, A., Gignoux, C., Fernandez-Lopez, J., Zakharia, F., Sikora, M., & Contreras, A. et al. (2014). The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Science, 344(6189), 1280-1285. http://dx.doi.org/10.1126/science.1251688 [link]

PLOS

22. Sikora, M., Carpenter, M., Moreno-Estrada, A., Henn, B., Underhill, P., & Sánchez-Quinto, F. et al. (2014). Population Genomic Analysis of Ancient and Modern Genomes Yields New Insights into the Genetic Ancestry of the Tyrolean Iceman and the Genetic Structure of Europe. PLOS Genetics, 10(5), e1004353. http://dx.doi.org/10.1371/journal.pgen.1004353 [link]

PLOS

21. Moreno-Estrada, A., Gravel, S., Zakharia, F., McCauley, J., Byrnes, J., & Gignoux, C. et al. (2013). Reconstructing the Population Genetic History of the Caribbean. PLOS Genetics, 9(11), e1003925. http://dx.doi.org/10.1371/journal.pgen.1003925 [link]

PLOS

20. Gravel, S., Zakharia, F., Moreno-Estrada, A., Byrnes, J., Muzzio, M., & Rodriguez-Flores, J. et al. (2013). Reconstructing Native American Migrations from Whole-Genome and Whole-Exome Data. PLOS Genetics, 9(12), e1004023. http://dx.doi.org/10.1371/journal.pgen.1004023 [link]

CUI

19. Moreno-Estrada, A., & Sandoval, K. (2013). Diversidad genómica en México. Pasado indígena y mestizaje. Cuicuilco, 20(58), 249-276. [link]

Cell

18. Carpenter, M., Buenrostro, J., Valdiosera, C., Schroeder, H., Allentoft, M., & Sikora, M. et al. (2013). Pulling out the 1%: Whole-Genome Capture for the Targeted Enrichment of Ancient DNA Sequencing Libraries. The American Journal Of Human Genetics, 93(5), 852-864. http://dx.doi.org/10.1016/j.ajhg.2013.10.002 [link]

Science

17. Kenny, E., Timpson, N., Sikora, M., Yee, M., Moreno-Estrada, A., & Eng, C. et al. (2012). Melanesian Blond Hair Is Caused by an Amino Acid Change in TYRP1. Science, 336(6081), 554-554. http://dx.doi.org/10.1126/science.1217849 [link]

AJPA

16. Sandoval, K., Moreno-Estrada, A., Mendizabal, I., Underhill, P., Lopez-Valenzuela, M., & Peñaloza-Espinosa, R. et al. (2012). Y-chromosome diversity in Native Mexicans reveals continental transition of genetic structure in the Americas. Am. J. Phys. Anthropol., 148(3), 395-405. http://dx.doi.org/10.1002/ajpa.22062 [link]

Cell

15. Kidd, J. M., Gravel, S., Byrnes, J., Moreno-Estrada, A., Musharoff, S., Bryc, K., ... & McLaughlin, S. F. (2012). Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. The American Journal of Human Genetics, 91(4), 660-671. [link]

Imm

14.Drake, K. A., Torgerson, D. G., Gignoux, C. R., Galanter, J. M., Roth, L. A., Huntsman, S., ... & Bustamante, C. D. (2014). A genome-wide association study of bronchodilator response in Latinos implicates rare variants. Journal of Allergy and Clinical Immunology, 133(2), 370-378. [link]

Imm

13.Kumar, R., Nguyen, E. A., Roth, L. A., Oh, S. S., Gignoux, C. R., Huntsman, S., ... & López-López, M. (2013). Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: the Genes-environments and Admixture in Latino Asthmatics (GALA II) study. Journal of Allergy and Clinical Immunology, 132(4), 896-905. [link]

Evol

12. Antolin, M., Jenkins, K., Bergstrom, C., Crespi, B., De, S., & Hancock, A. et al. (2012). Evolution and Medicine in Undergraduate Education: A Prescription for All Biology Students. Evolution, 66(6), 1991-2006. http://dx.doi.org/10.1111/j.1558-5646.2011.01552.x [link]

PLOS

11. Chen, R., Corona, E., Sikora, M., Dudley, J., Morgan, A., & Moreno-Estrada, A. et al. (2012). Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases. PLOS Genetics, 8(4), e1002621. http://dx.doi.org/10.1371/journal.pgen.1002621 [link]

PLOS

10. Henn, B., Botigué, L., Gravel, S., Wang, W., Brisbin, A., & Byrnes, J. et al. (2012). Genomic Ancestry of North Africans Supports Back-to-Africa Migrations. PLOS Genetics, 8(1), e1002397. http://dx.doi.org/10.1371/journal.pgen.1002397 [link]

Nature

9. Keller, A., Graefen, A., Ball, M., Matzas, M., Boisguerin, V., & Maixner, F. et al. (2012). New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing. Nature Communications, 3, 698. http://dx.doi.org/10.1038/ncomms1701 [link]

BMC

8. Moreno-Estrada, A., Aparicio-Prat, E., Sikora, M., Engelken, J., Ramírez-Soriano, A., Calafell, F., & Bosch, E. (2010). African signatures of recent positive selection in human FOXI1. BMC Evol Biol, 10(1), 267. http://dx.doi.org/10.1186/1471-2148-10-267 [link]

PNAS

7. Bryc, K., Velez, C., Karafet, T., Moreno-Estrada, A., Reynolds, A., & Auton, A. et al. (2010). Genome-wide patterns of population structure and admixture among Hispanic/Latino populations. Proceedings Of The National Academy Of Sciences, 107(Supplement_2), 8954-8961. http://dx.doi.org/10.1073/pnas.0914618107 [link]

Oxford

6. Henn, B., Gravel, S., Moreno-Estrada, A., Acevedo-Acevedo, S., & Bustamante, C. (2010). Fine-scale population structure and the era of next-generation sequencing. Human Molecular Genetics, 19(R2), R221-R226. http://dx.doi.org/10.1093/hmg/ddq403 [link]

Oxford

5. Acuna-Alonzo, V., Flores-Dorantes, T., Kruit, J., Villarreal-Molina, T., Arellano-Campos, O., & Hunemeier, T. et al. (2010). A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Human Molecular Genetics, 19(14), 2877-2885. http://dx.doi.org/10.1093/hmg/ddq173 [link]

Oxford

4. Moreno-Estrada, A., Tang, K., Sikora, M., Marques-Bonet, T., Casals, F., & Navarro, A. et al. (2009). Interrogating 11 Fast-Evolving Genes for Signatures of Recent Positive Selection in Worldwide Human Populations. Molecular Biology And Evolution, 26(10), 2285-2297. http://dx.doi.org/10.1093/molbev/msp134 [link]

BMC_G

3. Bosch, E., Laayouni, H., Morcillo-Suarez, C., Casals, F., Moreno-Estrada, A., & Ferrer-Admetlla, A. et al. (2009). Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD. BMC Genomics, 10(1), 338. http://dx.doi.org/10.1186/1471-2164-10-338 [link]

Oxford

2. Moreno-Estrada, A., Casals, F., Ramirez-Soriano, A., Oliva, B., Calafell, F., Bertranpetit, J., & Bosch, E. (2008). Signatures of Selection in the Human Olfactory Receptor OR5I1 Gene. Molecular Biology And Evolution, 25(1), 144-154. http://dx.doi.org/10.1093/molbev/msm240 [link]

Oxford

1. Morcillo-Suarez, C., Alegre, J., Sangros, R., Gazave, E., de Cid, R., & Milne, R. et al. (2008). SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data. Bioinformatics, 24(14), 1643-1644. http://dx.doi.org/10.1093/bioinformatics/btn241 [link]